The prevalence of polycystic ovarian syndrome (PCOS) in reproductive age women is around 8% to 13%. Many treatment options are available for PCOS associated symptoms including obesity, abnormal glucose metabolism, infertility, menstrual irregularity and hyperandrogenism. Double blinded, randomized clinical trial (RCT) was conducted on 302 PCOS women who referred to subfertility and gynaecology clinic, Teaching hospital, Kandy. Interviewer administered questionnaire was used for data collection. Mean age of the PCOS population was 30.82(SD=4.76) years and mean BMI was 27.64(SD=3.06kg/m2 ).Majority were overweight (67.9%) and the obesity prevalence was 13.2%. 8.94% had regular menstrual cycles and the majority were with irregular cycles (91.1%). 73.9% were oligomenorrheic, while 17.2% were amenorrhoeic among PCOS. The prevalence of acne was 70.2%. Hirsutism and acanthosis nigricans occurred in 66.89% and 55.29% of patients, respectively. In this study, 17.88% (n=54) were calcium deficient and 15. 23% were having impaired fasting glycaemia. 5.62% (n=17) of them were Diabetics. After treatment menstrual regularities were not significantly different between two groups. (p=0.477) But, the percentage difference within each group was statistically significant t(p=0.000). Both groups had a significant effect in their treatment while a notable better improvement on menstrual regularity observed within Metformin plus calcium group. Although the after treatment-BMI, among the groups was not significant (p=0.380), BMI reduced almost significantly within each group with their treatments. (p=0.000) Better reduction was seen with metformin plus calcium group.This trial showed an improvement with calcium on metformin in menstrual regularity and BMI in PCOS patients. Adding of cheap, safe and freely available calcium on metformin in Sri Lankan population would bring better clinical outcomes..
2022-09-01.
Download PDF